SETMAR

Across TCGA pan-cancer cohorts, SETMAR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SETMAR data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SETMAR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SETMAR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, HNSC, and CCRCC are the cancer types where SETMAR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.311	1.000	.001	36	view →
HNSC	OS	Tertile	II,III,IV	0.924	1.000	.009	30	view →
CCRCC	DFS	Tertile	II,III,IV	0.888	0.501	.005	18	view →
LSCC	DFS	Quartile	III,IV	0.495	0.917	.021	9	view →
PDAC	OS	Tertile	II,III,IV	0.307	0.632	.010	8	view →
LUAD	DFS	Tertile	All	0.850	0.488	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SETMAR–UCEC (OS)

Open the UCEC breakdown →