SETDB2

Across TCGA pan-cancer cohorts, SETDB2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SETDB2 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SETDB2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SETDB2 expression acts as an unfavorable survival marker.

UCEC and GBM are the cancer types where SETDB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.154	1.000	.038	8	view →
GBM	DFS	Tertile	All	0.468	0.954	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SETDB2–UCEC (OS)

Open the UCEC breakdown →