SETDB2

Across TCGA patient cohorts, SETDB2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,450 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SETDB2-associated genes across cancer lineages are EMD, LAPTM4B, and SQLE. Each is linked with SETDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETDB2-to-partner and partner-to-SETDB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SETDB2 versus EMD in UCEC, with a Pearson correlation of -0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB2→partner) and Y-score (partner→SETDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EMD →	-0.732	-0.507	.002	.008	3	2
UCEC	LAPTM4B →	-1.480	-0.545	<.001	.004	3	2
LUAD	SQLE →	-0.805	-0.478	.007	.003	3	2
UCEC	RTL8C →	-0.867	-0.585	.001	<.001	3	2
UCEC	NKIRAS2 →	-0.555	-0.627	.001	<.001	3	2
UCEC	DHCR7 →	-1.107	-0.711	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,450 associations by consensus.

SETDB2 vs EMD — UCEC

Explore this scatter interactively →