SETDB2

Across TCGA cell cohorts, SETDB2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,078 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SETDB2-associated GO terms across cancer lineages are Positive regulation of cytoplasmic mRNA processing body assembly, Negative regulation of hematopoietic stem cell differentiation, and Phosphatidylinositol metabolic process. Each is linked with SETDB2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SETDB2-to-partner and partner-to-SETDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic mRNA processing body assembly grouped by SETDB2-low versus SETDB2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB2→partner) and Y-score (partner→SETDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of cytoplasmic mRNA processing body assembly →	+0.136	+0.635	<.001	<.001	3	11
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.152	+0.796	<.001	<.001	3	10
OVARY	Phosphatidylinositol metabolic process →	+0.038	+0.458	.002	.007	1	11
BREAST	Golgi to endosome transport →	+0.079	+0.380	<.001	.002	3	8
STOMACH	Retrograde transport, vesicle recycling within Golgi →	+0.124	+1.090	.001	.001	3	8
SOFT_TISSUE	Regulation of cytoplasmic mRNA processing body assembly →	+0.119	+0.622	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,078 associations by consensus.

Positive regulation of cytoplasmic mRNA processing body assembly by SETDB2 expression — SOFT_TISSUE

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