SETDB2

Across TCGA cell cohorts, SETDB2 mutation is significantly associated with the RNA expression of many other genes, with 787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETDB2-associated genes across cancer lineages are LRRC3C, PRR27, and KCNK16. Each is linked with SETDB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETDB2-to-partner and partner-to-SETDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by SETDB2-low versus SETDB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB2→partner) and Y-score (partner→SETDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.226	+3.337	<.001	<.001	3	2
PANCREAS	PRR27 →	+0.023	+5.614	<.001	.002	3	1
PANCREAS	KCNK16 →	+0.040	+5.000	.007	.006	3	1
LARGE_INTESTINE	SLC16A8 →	+1.053	+3.234	<.001	.004	3	1
LARGE_INTESTINE	DNAL4 →	+0.573	+3.212	.003	.006	3	1
LARGE_INTESTINE	RPL3 →	+0.589	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 787 associations by consensus.

LRRC3C by SETDB2 expression — LARGE_INTESTINE

Explore this box plot interactively →