SETDB2

Across TCGA cell cohorts, SETDB2 mutation is significantly associated with the mutation status of many other genes, with 4,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETDB2-associated genes across cancer lineages are LYST, KLK4, and FMNL2. Each is linked with SETDB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SETDB2-to-partner and partner-to-SETDB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYST grouped by SETDB2-low versus SETDB2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETDB2→partner) and Y-score (partner→SETDB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LYST →	+2.977	+4.273	.006	.006	1	5
SKIN	KLK4 →	+5.392	+4.824	.004	.004	1	4
STOMACH	FMNL2 →	+4.807	+4.807	.008	.008	1	4
STOMACH	ALPG →	+4.807	+4.807	.008	.008	1	4
OVARY	TXLNB →	+4.562	+5.217	<.001	<.001	1	4
OVARY	PTCH1 →	+3.240	+4.467	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,558 associations by consensus.

LYST by SETDB2 expression — OVARY

Explore this box plot interactively →