SETD7

Across TCGA patient cohorts, SETD7 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD7-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, 14-3-3_beta, and EGFR_pY1068. Each is linked with SETD7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD7-to-partner and partner-to-SETD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by SETD7-low versus SETD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD7→partner) and Y-score (partner→SETD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.429	+2.232	.013	.005	3	2
UCEC	14-3-3_beta →	-0.089	-1.973	.009	.029	3	1
UCEC	EGFR_pY1068 →	-0.271	-1.807	.001	.004	3	1
UCEC	EGFR →	-0.168	-2.115	.002	.017	3	1
UCEC	A-Raf_pS299 →	-0.170	-1.906	<.001	.015	3	1
UCEC	ERK2 →	+0.135	+1.247	.039	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Acetyl-a-Tubulin-Lys40 by SETD7 expression — UCEC

Explore this box plot interactively →