SETD7

Across TCGA cell cohorts, SETD7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,349 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD7-associated GO terms across cancer lineages are Peptidyl-lysine dimethylation, Protein deubiquitination, and Phosphatidylinositol metabolic process. Each is linked with SETD7 in more than 14 cancer types. Because this analysis shows association rather than direction, both SETD7-to-partner and partner-to-SETD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine dimethylation grouped by SETD7-low versus SETD7-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD7→partner) and Y-score (partner→SETD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Peptidyl-lysine dimethylation →	+0.143	+1.254	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Protein deubiquitination →	+0.056	+0.990	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol metabolic process →	+0.046	+0.873	.002	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Phosphatidylinositol biosynthetic process →	+0.052	+0.802	<.001	.002	3	10
LUNG_NSCLC_LUSC	Regulation of SREBP signaling pathway →	+0.099	+0.708	.004	.005	3	9
LARGE_INTESTINE	COPII-coated vesicle cargo loading →	+0.082	+0.728	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,349 associations by consensus.

Peptidyl-lysine dimethylation by SETD7 expression — SOFT_TISSUE

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