SETD6

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SETD6 protein abundance is significantly associated with the RNA expression of many other genes, with 1,320 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SETD6-associated genes across cancer lineages are MESP1, SLC7A11, and DUSP4. Each is linked with SETD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD6-to-partner and partner-to-SETD6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SETD6 versus MESP1 in PDAC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD6→partner) and Y-score (partner→SETD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACMESP1 →+0.682+0.522<.001.00132
LUADSLC7A11 →+2.382+0.784<.001<.00132
LUADDUSP4 →+2.094+0.716<.001.00132
BRCANDUFAF1 →+0.483+0.361<.001<.00132
BRCALINC00589 →+0.655+0.294.004<.00132
BRCARHEX →-1.099-0.277<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,320 associations by consensus.

SETD6 vs MESP1 — PDAC

Per-sample scatter of SETD6 vs MESP1 in PDAC (Pearson r = 0.55).

Explore this scatter interactively →

Exploration