SETD6

Across TCGA patient cohorts, SETD6 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD6-associated genes across cancer lineages are OR10G3, RN7SL822P, and FRG2HP. Each is linked with SETD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD6-to-partner and partner-to-SETD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G3 grouped by SETD6-low versus SETD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD6→partner) and Y-score (partner→SETD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR10G3 →	+0.188	+3.425	.008	<.001	3	2
LUSC	RN7SL822P →	+0.167	+5.133	<.001	<.001	3	2
LUSC	FRG2HP →	+0.409	+4.067	.003	.005	3	2
BLCA	RNU6-1242P →	+0.443	+3.973	<.001	.003	3	1
BLCA	TUBB4BP7 →	+0.026	+3.479	.001	.008	3	1
BLCA	RNA5SP113 →	+0.383	+4.618	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

OR10G3 by SETD6 expression — UCEC

Explore this box plot interactively →