SETD6

Across TCGA patient cohorts, SETD6 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD6-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Src_pY527, and Bax. Each is linked with SETD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD6-to-partner and partner-to-SETD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SETD6-low versus SETD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD6→partner) and Y-score (partner→SETD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.616	-3.000	.017	.036	3	1
UCEC	Src_pY527 →	-0.649	-3.000	.009	.037	3	1
UCEC	Bax →	+0.302	+2.817	.029	.036	3	1
UCEC	p62 Lck ligand →	+0.498	+3.000	.008	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

p38-MAPK_pT180_Y182 by SETD6 expression — UCEC

Explore this box plot interactively →