SETD6

Across TCGA cell cohorts, SETD6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,821 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SETD6-associated GO terms across cancer lineages are Protein-RNA complex assembly, Peptidyl-lysine monomethylation, and RNA catabolic process. Each is linked with SETD6 in more than 13 cancer types. Because this analysis shows association rather than direction, both SETD6-to-partner and partner-to-SETD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-RNA complex assembly grouped by SETD6-low versus SETD6-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD6→partner) and Y-score (partner→SETD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein-RNA complex assembly →	+0.067	+1.050	.003	.006	3	14
BONE	Peptidyl-lysine monomethylation →	+0.121	+1.504	<.001	<.001	3	13
OESOPHAGUS	RNA catabolic process →	+0.054	+0.816	.006	.007	3	12
LARGE_INTESTINE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.106	+0.874	<.001	<.001	3	12
LUNG_SCLC	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.116	+1.145	.002	.002	3	11
LUNG_SCLC	Peptidyl-lysine modification →	+0.044	+0.925	.001	.002	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,821 associations by consensus.

Protein-RNA complex assembly by SETD6 expression — LUNG_SCLC

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