SETD6

Across TCGA cell cohorts, SETD6 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD6-associated genes across cancer lineages are ASB17, ADRA1A, and KRTAP21-2. Each is linked with SETD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD6-to-partner and partner-to-SETD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by SETD6-low versus SETD6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD6→partner) and Y-score (partner→SETD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
BLOOD_Leukemia	ADRA1A →	+0.214	+4.705	<.001	.003	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.062	+4.539	.001	.007	3	1
BLOOD_Leukemia	RTP2 →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	FAM24A →	+0.061	+4.969	<.001	.003	3	1
CNS	ZAN →	+0.004	+4.754	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ASB17 by SETD6 expression — OVARY

Explore this box plot interactively →