SETD5

Across TCGA patient cohorts, SETD5 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD5-associated genes across cancer lineages are FoxM1, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with SETD5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SETD5-to-partner and partner-to-SETD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SETD5-low versus SETD5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD5→partner) and Y-score (partner→SETD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.145	+1.321	.044	.005	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.335	-1.353	.007	.013	3	3
UCEC	PDCD4 →	-0.462	-1.321	<.001	.005	3	3
UCEC	ATM →	-0.611	-2.321	<.001	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.091	-1.459	.008	.009	3	2
UCEC	Notch1 →	+0.141	+2.013	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

FoxM1 by SETD5 expression — UCEC

Explore this box plot interactively →