SETD5

Across TCGA cell cohorts, SETD5 mutation is significantly associated with the RNA expression of many other genes, with 82 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SETD5-associated genes across cancer lineages are IL22, PVALB, and CCNP. Each is linked with SETD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD5-to-partner and partner-to-SETD5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by SETD5-low versus SETD5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD5→partner) and Y-score (partner→SETD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL22 →	+0.018	+3.984	<.001	.006	3	2
CNS	PVALB →	+0.691	+2.490	<.001	.008	3	2
SOFT_TISSUE	CCNP →	+0.206	+3.273	.001	.009	2	2
SOFT_TISSUE	RFPL3 →	+0.072	+2.637	<.001	.009	3	1
SOFT_TISSUE	PMP2 →	+0.825	+3.708	.004	.004	3	1
SOFT_TISSUE	LALBA →	+0.773	+3.297	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

IL22 by SETD5 expression — BLOOD_Leukemia

Explore this box plot interactively →