Across TCGA patient cohorts, SETD4 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,465 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SETD4-associated proteins across cancer lineages are WDR5, SCAF4, and PAXBP1. Each is linked with SETD4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SETD4-to-partner and partner-to-SETD4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD4→partner) and Y-score (partner→SETD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR5 →	+0.271	+0.494	<.001	<.001	3	5
LUAD	SCAF4 →	+0.279	+0.513	<.001	<.001	3	5
LSCC	PAXBP1 →	+0.217	+0.487	<.001	<.001	3	5
LSCC	DHX9 →	+0.284	+0.558	<.001	<.001	3	5
GBM	ZBTB33 →	+0.382	+0.404	<.001	<.001	3	4
LSCC	RCSD1_S351 →	-0.717	-0.707	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,465 associations by consensus.

Exploration

SETD4 survival (RNA) · tumor vs normal (RNA) · all SETD4 data types