Across TCGA patient cohorts, SETD4 mutation is significantly associated with the RNA expression of many other genes, with 2,326 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD4-associated genes across cancer lineages are RNU6-650P, OR8J1, and RNA5SP413. Each is linked with SETD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD4-to-partner and partner-to-SETD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD4→partner) and Y-score (partner→SETD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-650P →	+0.390	+5.392	<.001	.002	3	2
LUAD	OR8J1 →	+0.019	+7.930	<.001	.008	3	2
LUAD	RNA5SP413 →	+0.188	+7.930	<.001	.008	3	2
SKCM	OR7E162P →	+0.046	+3.010	<.001	.006	3	2
SKCM	ZFRP1 →	+0.011	+4.039	<.001	.009	3	2
UCEC	NPAT →	+0.470	+2.415	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,326 associations by consensus.

Exploration

SETD4 survival (RNA) · tumor vs normal (RNA) · all SETD4 data types