Across TCGA patient cohorts, SETD4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD4-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and Caveolin-1. Each is linked with SETD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD4-to-partner and partner-to-SETD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD4→partner) and Y-score (partner→SETD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.466	+2.999	.047	.035	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.302	.021	.034	3	2
UCEC	Caveolin-1 →	-0.652	-2.999	.039	.035	3	2
UCEC	eIF4E →	+0.222	+3.013	.015	.018	3	1
UCEC	eIF4G →	+0.280	+3.169	.038	.019	3	1
UCEC	ERK2 →	+0.182	+2.807	.031	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

SETD4 survival (RNA) · tumor vs normal (RNA) · all SETD4 data types