Across TCGA cell cohorts, SETD4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SETD4-associated genes across cancer lineages are TMEM235, BTNL2, and BMP15. Each is linked with SETD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD4-to-partner and partner-to-SETD4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD4→partner) and Y-score (partner→SETD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM235 →	+0.011	+4.467	<.001	.004	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

SETD4 survival (RNA) · tumor vs normal (RNA) · all SETD4 data types