SETD3

Across TCGA patient cohorts, SETD3 mutation is significantly associated with the RNA expression of many other genes, with 945 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD3-associated genes across cancer lineages are LINC02304, SNRPCP18, and IL9. Each is linked with SETD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD3-to-partner and partner-to-SETD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02304 grouped by SETD3-low versus SETD3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD3→partner) and Y-score (partner→SETD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02304 →	+0.052	+4.165	<.001	<.001	3	2
SKCM	SNRPCP18 →	+0.038	+3.624	<.001	.002	3	2
COAD	IL9 →	+0.155	+3.769	<.001	.002	3	2
COAD	LSP1P3 →	+0.739	+4.207	<.001	.001	3	2
UCEC	EML2-AS1 →	+0.067	+1.592	<.001	.006	3	2
LUAD	SNORD115-35 →	+0.598	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 945 associations by consensus.

LINC02304 by SETD3 expression — SKCM

Explore this box plot interactively →