SETD3

Across TCGA cell cohorts, SETD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,642 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD3-associated GO terms across cancer lineages are Monoubiquitinated protein deubiquitination, Positive regulation of cell cycle, and Mitotic G2/M transition checkpoint. Each is linked with SETD3 in more than 13 cancer types. Because this analysis shows association rather than direction, both SETD3-to-partner and partner-to-SETD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monoubiquitinated protein deubiquitination grouped by SETD3-low versus SETD3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD3→partner) and Y-score (partner→SETD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Monoubiquitinated protein deubiquitination →	+0.162	+0.781	<.001	<.001	3	14
BLOOD_Leukemia	Positive regulation of cell cycle →	+0.041	+0.380	<.001	<.001	3	12
KIDNEY	Mitotic G2/M transition checkpoint →	+0.050	+0.566	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Spliceosome-depend formation of circular RNA →	+0.199	+0.887	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.081	+0.845	.006	.002	2	11
KIDNEY	Meiotic cell cycle →	+0.048	+0.658	.007	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,642 associations by consensus.

Monoubiquitinated protein deubiquitination by SETD3 expression — LIVER

Explore this box plot interactively →