SETD3

Across TCGA cell cohorts, SETD3 protein abundance is significantly associated with the RNA expression of many other genes, with 5,830 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD3-associated genes across cancer lineages are HSPG2, TAPBP, and RBKS. Each is linked with SETD3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SETD3-to-partner and partner-to-SETD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SETD3 versus HSPG2 in LUNG_NSCLC_LUSC, with a Pearson correlation of -0.80.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD3→partner) and Y-score (partner→SETD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HSPG2 →	-4.359	-1.056	.005	.003	3	6
URINARY_TRACT	TAPBP →	-1.636	-2.443	.001	<.001	3	6
LIVER	RBKS →	-1.469	-1.914	.001	.002	3	6
BLOOD_Leukemia	CITED4 →	-1.433	-0.565	.005	.003	3	6
BLOOD_Leukemia	MARCKSL1 →	+1.195	+0.569	.001	.003	3	6
LUNG_SCLC	HMGB2 →	+0.788	+0.745	.002	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,830 associations by consensus.

SETD3 vs HSPG2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →