SETD3

Across TCGA cell cohorts, SETD3 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,845 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD3-associated GO terms across cancer lineages are Negative regulation of protein catabolic process, Acrosomal vesicle exocytosis, and Negative regulation of proteolysis. Each is linked with SETD3 in more than 6 cancer types. Because this analysis shows association rather than direction, both SETD3-to-partner and partner-to-SETD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein catabolic process grouped by SETD3-low versus SETD3-high in PANCREAS.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD3→partner) and Y-score (partner→SETD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of protein catabolic process →	-0.080	-1.905	.007	.001	3	7
STOMACH	Acrosomal vesicle exocytosis →	+1.615	+1.648	<.001	.003	3	6
BLOOD_Leukemia	Negative regulation of proteolysis →	-0.084	-0.571	<.001	.002	3	6
LARGE_INTESTINE	Synaptic vesicle docking →	+0.199	+0.730	.002	.001	2	6
BLOOD_Leukemia	Fusion of virus membrane with host plasma membrane →	-0.935	-0.745	<.001	.001	3	5
LUNG_NSCLC_LUSC	Columnar/cuboidal epithelial cell development →	-0.316	-0.990	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,845 associations by consensus.

Negative regulation of protein catabolic process by SETD3 expression — PANCREAS

Explore this box plot interactively →