SETD2

Across TCGA patient cohorts, SETD2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,513 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SETD2-associated proteins across cancer lineages are QRICH1, TOP2B, and EPM2AIP1. Each is linked with SETD2 in more than 7 cancer types. Because this analysis shows association rather than direction, both SETD2-to-partner and partner-to-SETD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SETD2 versus QRICH1 in LSCC, with a Pearson correlation of 0.52.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD2→partner) and Y-score (partner→SETD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	QRICH1 →	+0.246	+0.385	<.001	<.001	3	8
HNSC	TOP2B →	+0.453	+0.397	<.001	.001	3	6
BRCA	EPM2AIP1 →	+0.313	+0.399	<.001	<.001	3	6
GBM	HNRNPLL →	+0.400	+0.430	<.001	<.001	3	6
GBM	RBM15B →	+0.303	+0.428	<.001	<.001	3	5
HNSC	TRRAP →	+0.213	+0.601	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,513 associations by consensus.

SETD2 vs QRICH1 — LSCC

Explore this scatter interactively →