SETD2

Across TCGA patient cohorts, SETD2 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD2-associated genes across cancer lineages are Heregulin, NF2, and NF-kB-p65_pS536. Each is linked with SETD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SETD2-to-partner and partner-to-SETD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by SETD2-low versus SETD2-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD2→partner) and Y-score (partner→SETD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Heregulin →	+0.172	+1.591	.014	.023	3	4
SKCM	NF2 →	+0.304	+3.459	.005	.004	3	4
SKCM	NF-kB-p65_pS536 →	-0.338	-1.700	.040	.043	3	4
UCEC	p53 →	-0.264	-1.440	.004	.020	3	3
KIRC	53BP1 →	+0.206	+1.999	.025	.030	3	3
COAD	p27_pT157 →	+0.206	+1.882	<.001	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

Heregulin by SETD2 expression — KIRC

Explore this box plot interactively →