SETD2

Across TCGA cell cohorts, SETD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,796 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD2-associated GO terms across cancer lineages are Regulation of RNA export from nucleus, RNA destabilization, and Regulation of mRNA export from nucleus. Each is linked with SETD2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SETD2-to-partner and partner-to-SETD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA export from nucleus grouped by SETD2-low versus SETD2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD2→partner) and Y-score (partner→SETD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of RNA export from nucleus →	+0.119	+0.418	<.001	<.001	3	18
SOFT_TISSUE	RNA destabilization →	+0.063	+0.701	<.001	.003	3	18
STOMACH	Regulation of mRNA export from nucleus →	+0.122	+0.704	<.001	<.001	3	17
SOFT_TISSUE	Negative regulation of chromosome condensation →	+0.151	+0.591	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.070	+0.920	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of DNA repair →	+0.048	+0.486	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,796 associations by consensus.

Regulation of RNA export from nucleus by SETD2 expression — BONE

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