SETD2

Across TCGA cell cohorts, SETD2 mutation is significantly associated with the RNA expression of many other genes, with 1,600 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETD2-associated genes across cancer lineages are IFNA5, ANGPTL5, and OR2L13. Each is linked with SETD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SETD2-to-partner and partner-to-SETD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA5 grouped by SETD2-low versus SETD2-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD2→partner) and Y-score (partner→SETD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IFNA5 →	+0.029	+2.263	<.001	.008	3	2
SOFT_TISSUE	ANGPTL5 →	+0.100	+3.584	.002	.006	3	2
SOFT_TISSUE	OR2L13 →	+0.151	+3.422	.003	<.001	3	2
KIDNEY	BSND →	+0.034	+2.552	.006	.008	3	2
LARGE_INTESTINE	TMEM31 →	+0.360	+3.678	<.001	<.001	3	2
KIDNEY	ARID3C →	+0.199	+3.341	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,600 associations by consensus.

IFNA5 by SETD2 expression — KIDNEY

Explore this box plot interactively →