SETD1B

Across TCGA pan-cancer cohorts, SETD1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SETD1B data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SETD1B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SETD1B expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where SETD1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.771	0.950	<.001	42	view →
LSCC	DFS	Median	II,III,IV	1.000	0.834	.005	40	view →
CCRCC	DFS	Median	II,III,IV	0.942	0.128	.007	31	view →
GBM	DFS	Quartile	All	0.527	0.261	<.001	21	view →
PDAC	DFS	Median	III,IV	0.520	0.234	.035	9	view →
LUAD	DFS	Median	II,III,IV	1.000	0.798	.015	4	view →
UCEC	OS	Median	All	0.847	0.982	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SETD1B–HNSC (OS)

Open the HNSC breakdown →