SETD1B

Across TCGA patient cohorts, SETD1B mutation is significantly associated with the RNA expression of many other genes, with 2,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SETD1B-associated genes across cancer lineages are MIR7843, S100A7L2, and RNA5SP447. Each is linked with SETD1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SETD1B-to-partner and partner-to-SETD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7843 grouped by SETD1B-low versus SETD1B-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1B→partner) and Y-score (partner→SETD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR7843 →	+0.317	+4.902	<.001	.003	3	2
CESC	S100A7L2 →	+0.099	+4.010	<.001	.002	3	2
CESC	RNA5SP447 →	+0.269	+4.201	.001	.002	3	2
COAD	TMEM269 →	+0.184	+2.807	.001	.003	3	2
SARC	OR51A1P →	+0.064	+6.649	<.001	<.001	3	2
CESC	RNA5SP281 →	+0.186	+4.837	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

MIR7843 by SETD1B expression — LIHC

Explore this box plot interactively →