SETD1B

Across TCGA cell cohorts, SETD1B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,960 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SETD1B-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Epigenetic regulation of gene expression. Each is linked with SETD1B in more than 17 cancer types. Because this analysis shows association rather than direction, both SETD1B-to-partner and partner-to-SETD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SETD1B-low versus SETD1B-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1B→partner) and Y-score (partner→SETD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.180	+0.987	<.001	<.001	3	18
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.231	+1.291	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.077	+1.338	<.001	<.001	3	18
STOMACH	Negative regulation of autophagy →	+0.090	+0.983	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of RNA splicing →	+0.085	+0.760	<.001	<.001	3	17
BONE	Nucleic acid transport →	+0.112	+0.922	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,960 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SETD1B expression — URINARY_TRACT

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