SETD1B

Across TCGA cell cohorts, SETD1B mutation is significantly associated with the RNA expression of many other genes, with 2,200 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SETD1B-associated genes across cancer lineages are CENPH, SMU1, and HJURP. Each is linked with SETD1B in more than 2 cancer types. Because this analysis shows association rather than direction, both SETD1B-to-partner and partner-to-SETD1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPH grouped by SETD1B-low versus SETD1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SETD1B→partner) and Y-score (partner→SETD1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CENPH →	+0.474	+2.252	.009	.003	3	3
LARGE_INTESTINE	SMU1 →	+0.361	+2.115	<.001	.004	3	3
LARGE_INTESTINE	HJURP →	+0.486	+1.628	.004	.002	3	3
LARGE_INTESTINE	WDR36 →	+0.514	+1.628	.003	.002	3	3
LARGE_INTESTINE	NEDD1 →	+0.513	+1.628	<.001	.002	3	3
LARGE_INTESTINE	PLK4 →	+0.572	+1.628	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,200 associations by consensus.

CENPH by SETD1B expression — BLOOD_Leukemia

Explore this box plot interactively →