SETD1A

Across TCGA pan-cancer cohorts, SETD1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SETD1A data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SETD1A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SETD1A expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where SETD1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.596	0.858	.002	58	view →
LSCC	DFS	Median	All	0.884	0.569	<.001	30	view →
GBM	OS	Median	All	0.475	0.294	.016	4	view →
PDAC	DFS	Tertile	IV	0.752	0.199	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SETD1A–HNSC (OS)

Open the HNSC breakdown →