SETBP1-DT

Across TCGA pan-cancer cohorts, SETBP1-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SETBP1-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher SETBP1-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SETBP1-DT expression acts as an unfavorable survival marker, although some lineages such as PAAD and KIRC show a favorable association.

UVM, BLCA, and PAAD are the cancer types where SETBP1-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.423	0.885	<.001	129	view →
BLCA	DFS	Median	All	0.258	0.419	<.001	107	view →
PAAD	OS	Tertile	All	0.603	0.265	<.001	76	view →
KIRC	DFS	Median	All	0.727	0.547	<.001	58	view →
UCS	OS	Quartile	II,III,IV	0.731	0.162	.003	58	view →
BRCA	OS	Median	III,IV	0.892	0.765	.001	50	view →
LIHC	OS	Median	All	0.439	0.678	.002	35	view →
THYM	DFS	Median	All	0.934	0.795	.005	20	view →
ESCA	DFS	Tertile	III,IV	0.503	0.293	.023	16	view →
MESO	DFS	Quartile	IV	0.864	0.285	.006	13	view →
ACC	DFS	Tertile	III,IV	0.426	0.089	.007	11	view →
CHOL	DFS	Median	All	0.643	0.176	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SETBP1-DT–UVM (OS)

Open the UVM breakdown →