SET

Across TCGA pan-cancer cohorts, SET Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SET data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SET Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SET expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, STAD, and UCEC are the cancer types where SET Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.111	0.835	<.001	36	view →
STAD	OS	Median	All	0.001	0.667	<.001	30	view →
UCEC	DFS	Median	All	1.000	0.828	.013	22	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SET–LUAD (OS)

Open the LUAD breakdown →