SET

Across TCGA patient cohorts, SET mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SET-associated genes across cancer lineages are PCNA, Rad50, and EGFR. Each is linked with SET in more than 1 cancer types. Because this analysis shows association rather than direction, both SET-to-partner and partner-to-SET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SET-low versus SET-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SET→partner) and Y-score (partner→SET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.179	+1.584	.035	.036	3	2
UCEC	Rad50 →	-0.192	-2.502	.043	.002	3	2
UCEC	EGFR →	-0.201	-3.459	.001	.005	3	1
UCEC	Gab2 →	+0.340	+2.999	.015	.035	3	1
UCEC	MEK1 →	+0.476	+4.247	<.001	<.001	3	1
UCEC	Notch1 →	+0.187	+2.502	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by SET expression — UCEC

Explore this box plot interactively →