SET

Across TCGA cell cohorts, SET RNA expression is significantly associated with the go_rna of many other GO terms, with 5,413 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SET-associated GO terms across cancer lineages are Immunoglobulin heavy chain V-D-J recombination, Positive regulation of chromosome condensation, and V(D)J recombination. Each is linked with SET in more than 19 cancer types. Because this analysis shows association rather than direction, both SET-to-partner and partner-to-SET results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Immunoglobulin heavy chain V-D-J recombination grouped by SET-low versus SET-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SET→partner) and Y-score (partner→SET) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Immunoglobulin heavy chain V-D-J recombination →	+0.217	+0.936	<.001	<.001	3	20
PANCREAS	Positive regulation of chromosome condensation →	+0.225	+0.812	<.001	<.001	3	20
SOFT_TISSUE	V(D)J recombination →	+0.161	+0.933	<.001	<.001	3	19
STOMACH	Positive regulation of cell cycle process →	+0.091	+0.625	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of G2/M transition of mitotic cell cycle →	+0.082	+1.107	.001	<.001	3	18
BREAST	Regulation of cell cycle checkpoint →	+0.108	+0.837	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,413 associations by consensus.

Immunoglobulin heavy chain V-D-J recombination by SET expression — BREAST

Explore this box plot interactively →