Across TCGA pan-cancer cohorts, SESTD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SESTD1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SESTD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SESTD1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

CCRCC, GBM, and LSCC are the cancer types where SESTD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.952	0.743	<.001	55	view →
GBM	DFS	Tertile	All	0.482	0.251	<.001	18	view →
LSCC	DFS	Median	II,III,IV	0.816	1.000	.001	17	view →
HNSC	DFS	Tertile	IV	0.507	0.823	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SESTD1 tumor-vs-normal RNA expression · all SESTD1 data types