SESTD1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SESTD1 mutation is significantly associated with the RNA expression of many other genes, with 5,366 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SESTD1-associated genes across cancer lineages are RNU6ATAC30P, MCM5, and MTHFD1. Each is linked with SESTD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SESTD1-to-partner and partner-to-SESTD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESTD1→partner) and Y-score (partner→SESTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCRNU6ATAC30P →+0.424+4.245<.001<.00133
UCECMCM5 →+0.548+2.606<.001<.00133
UCECMTHFD1 →+0.628+2.606<.001<.00133
UCECOIP5 →+0.944+2.214<.001<.00133
UCECPSMD9 →+0.395+1.954<.001<.00133
UCECMRPL18 →+0.439+1.769<.001<.00133
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,366 associations by consensus.

Exploration