Across TCGA cell cohorts, SESTD1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SESTD1-associated genes across cancer lineages are ECE2, TBC1D21, and C12orf40. Each is linked with SESTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SESTD1-to-partner and partner-to-SESTD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESTD1→partner) and Y-score (partner→SESTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.336	+4.054	<.001	.004	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C12orf40 →	+0.009	+3.684	<.001	.006	3	1
BLOOD_Leukemia	OR4N4 →	+0.021	+3.289	.005	.009	3	1
BLOOD_Leukemia	OR6J1 →	+0.045	+3.234	<.001	.008	3	1
BLOOD_Leukemia	SCT →	+0.289	+3.623	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

SESTD1 survival (RNA) · tumor vs normal (RNA) · all SESTD1 data types