SESN3

Across TCGA patient cohorts, SESN3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SESN3-associated genes across cancer lineages are Akt_pS473, Akt_pT308, and PCNA. Each is linked with SESN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SESN3-to-partner and partner-to-SESN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pS473 grouped by SESN3-low versus SESN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN3→partner) and Y-score (partner→SESN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pS473 →	+0.679	+2.115	.004	.016	3	2
UCEC	Akt_pT308 →	+0.680	+3.906	.001	<.001	3	2
UCEC	PCNA →	+0.199	+1.906	.005	.015	3	2
UCEC	Rab11 →	-0.150	-2.584	.002	<.001	3	2
UCEC	STAT3_pY705 →	-0.325	-2.087	<.001	.004	3	2
UCEC	Chk2_pT68 →	-0.176	-3.781	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

Akt_pS473 by SESN3 expression — UCEC

Explore this box plot interactively →