SESN2

Across TCGA patient cohorts, SESN2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SESN2-associated genes across cancer lineages are mTOR_pS2448, c-Met_pY1235, and FoxM1. Each is linked with SESN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SESN2-to-partner and partner-to-SESN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SESN2-low versus SESN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN2→partner) and Y-score (partner→SESN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.188	-2.980	.016	.036	3	2
UCEC	c-Met_pY1235 →	+0.084	+3.321	.030	.010	3	2
UCEC	FoxM1 →	+0.375	+3.321	.005	.010	3	1
UCEC	Ku80 →	+0.247	+2.820	.046	.035	3	1
UCEC	Notch1 →	+0.152	+3.321	.039	.010	3	1
UCEC	PCNA →	+0.397	+3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

mTOR_pS2448 by SESN2 expression — UCEC

Explore this box plot interactively →