SESN2

Across TCGA cell cohorts, SESN2 mutation is significantly associated with the mutation status of many other genes, with 975 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SESN2-associated genes across cancer lineages are RTL5, CNTN4, and GPRC5C. Each is linked with SESN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SESN2-to-partner and partner-to-SESN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RTL5 grouped by SESN2-low versus SESN2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SESN2→partner) and Y-score (partner→SESN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RTL5 →	+5.000	+4.187	.008	.008	1	3
SKIN	CNTN4 →	+3.187	+3.963	.001	.001	1	3
BLOOD_Leukemia	GPRC5C →	+4.309	+4.560	.007	.007	1	3
BLOOD_Lymphoma	NUP98 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	IQSEC3 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	EPX →	+6.014	+6.014	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 975 associations by consensus.

RTL5 by SESN2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →