SESN1

Across TCGA pan-cancer cohorts, SESN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SESN1 data layer compared with 27 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SESN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SESN1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where SESN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.822	0.281	.004	27	view →
CCRCC	OS	Median	All	0.894	0.747	.008	10	view →
PDAC	DFS	Quartile	II,III,IV	0.612	0.299	.014	4	view →
HNSC	DFS	Median	IV	0.776	0.540	.031	3	view →
LSCC	DFS	Median	All	0.894	0.518	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SESN1–LUAD (DFS)

Open the LUAD breakdown →