SERTM2

Across TCGA patient cohorts, SERTM2 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERTM2-associated genes across cancer lineages are AQP7P3, RPL14P6, and RNU6-1082P. Each is linked with SERTM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERTM2-to-partner and partner-to-SERTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP7P3 grouped by SERTM2-low versus SERTM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTM2→partner) and Y-score (partner→SERTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AQP7P3 →	+0.025	+4.260	.005	.007	3	1
UCEC	RPL14P6 →	+0.233	+3.169	.004	.006	3	1
UCEC	RNU6-1082P →	+0.434	+4.136	<.001	.001	3	1
UCEC	RNU1-133P →	+0.243	+4.727	<.001	.003	3	1
UCEC	RN7SKP230 →	+0.390	+3.576	.009	.006	3	1
UCEC	RNU6-431P →	+0.764	+3.938	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

AQP7P3 by SERTM2 expression — UCEC

Explore this box plot interactively →