SERTM2

Across TCGA cell cohorts, SERTM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 266 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SERTM2-associated GO terms across cancer lineages are Growth hormone receptor signaling pathway via JAK-STAT, Regulation of complement activation, alternative pathway, and Mitochondrial membrane organization. Each is linked with SERTM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERTM2-to-partner and partner-to-SERTM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone receptor signaling pathway via JAK-STAT grouped by SERTM2-low versus SERTM2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTM2→partner) and Y-score (partner→SERTM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Growth hormone receptor signaling pathway via JAK-STAT →	+0.142	+0.323	.001	.006	3	3
BLOOD_Leukemia	Regulation of complement activation, alternative pathway →	+0.651	+0.098	.006	.008	3	3
SKIN	Mitochondrial membrane organization →	+0.059	+0.160	<.001	.009	3	2
LUNG_SCLC	Purine ribonucleotide biosynthetic process →	+0.052	+0.313	.007	.006	2	3
BLOOD_Lymphoma	Protein import →	+0.234	+0.553	<.001	.008	3	2
BLOOD_Lymphoma	Negative regulation of activation of membrane attack complex →	+0.499	+0.562	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 266 associations by consensus.

Growth hormone receptor signaling pathway via JAK-STAT by SERTM2 expression — KIDNEY

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