SERTM1

Across TCGA patient cohorts, SERTM1 mutation is significantly associated with the RNA expression of many other genes, with 2,116 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERTM1-associated genes across cancer lineages are GAGE2E, CPSF7, and PELO. Each is linked with SERTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERTM1-to-partner and partner-to-SERTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE2E grouped by SERTM1-low versus SERTM1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTM1→partner) and Y-score (partner→SERTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	GAGE2E →	+0.131	+5.149	<.001	.003	3	2
UCEC	CPSF7 →	+0.357	+2.032	.006	.005	3	2
UCEC	PELO →	+0.443	+3.743	.004	<.001	3	2
SKCM	CENPH →	+0.727	+3.198	.002	.009	3	2
UCEC	SKA1 →	+0.865	+3.828	<.001	<.001	3	2
UCEC	EME1 →	+0.742	+3.743	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,116 associations by consensus.

GAGE2E by SERTM1 expression — LIHC

Explore this box plot interactively →