SERTM1

Across TCGA patient cohorts, SERTM1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERTM1-associated genes across cancer lineages are FoxM1, ASNS, and ATM. Each is linked with SERTM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERTM1-to-partner and partner-to-SERTM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SERTM1-low versus SERTM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTM1→partner) and Y-score (partner→SERTM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.275	+1.807	.010	.027	3	2
UCEC	ASNS →	+0.499	+2.000	<.001	.030	3	2
UCEC	ATM →	-0.585	-2.321	.001	.006	3	2
UCEC	C-Raf →	+0.209	+1.807	<.001	.027	3	2
SKCM	Rictor →	+0.480	+3.000	.009	.036	3	1
UCEC	EGFR_pY1068 →	-0.323	-3.000	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

FoxM1 by SERTM1 expression — UCEC

Explore this box plot interactively →