Across TCGA pan-cancer cohorts, SERTAD4-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SERTAD4-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where SERTAD4-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SERTAD4-AS1 is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.

UCEC, LIHC, and LUSC are the cancer types where SERTAD4-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SERTAD4-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	III,IV	−3.240	<.001	8	view →
LIHC	All	II,III,IV	+0.688	<.001	7	view →
LUSC	All	II,III,IV	−0.672	.001	7	view →
COAD	All	II,III,IV	−0.942	<.001	6	view →
BRCA	Female	II,III,IV	−0.674	<.001	6	view →
LUAD	Male	III,IV	−1.408	.004	5	view →
BLCA	Male	All	−1.359	.007	5	view →
STAD	All	All	−1.030	.008	5	view →
READ	All	All	−2.002	.003	3	view →
KICH	All	All	−1.130	.002	3	view →
KIRP	All	All	+0.625	.003	3	view →
CHOL	All	All	+1.016	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: SERTAD4-AS1 RNA expression & survival · all SERTAD4-AS1 data types