SERTAD2

Across TCGA patient cohorts, SERTAD2 mutation is significantly associated with the RNA expression of many other genes, with 4,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERTAD2-associated genes across cancer lineages are TUBGCP5, UHRF1, and PIGPP3. Each is linked with SERTAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SERTAD2-to-partner and partner-to-SERTAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBGCP5 grouped by SERTAD2-low versus SERTAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERTAD2→partner) and Y-score (partner→SERTAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBGCP5 →	+0.417	+1.787	<.001	<.001	3	2
UCEC	UHRF1 →	+0.741	+2.283	<.001	<.001	3	2
COAD	PIGPP3 →	+0.159	+3.280	<.001	.008	3	2
COAD	RNA5SP165 →	+0.262	+3.343	.002	.007	3	2
CESC	OR8B6P →	+0.026	+4.247	<.001	.007	3	2
UCEC	TAOK2 →	+0.328	+3.711	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,807 associations by consensus.

TUBGCP5 by SERTAD2 expression — UCEC

Explore this box plot interactively →