SERPINI2

Across TCGA patient cohorts, SERPINI2 mutation is significantly associated with the RNA expression of many other genes, with 4,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SERPINI2-associated genes across cancer lineages are UBL4A, MIR1231, and PPP2R2D. Each is linked with SERPINI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SERPINI2-to-partner and partner-to-SERPINI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBL4A grouped by SERPINI2-low versus SERPINI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SERPINI2→partner) and Y-score (partner→SERPINI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBL4A →	+0.341	+3.016	.007	<.001	3	3
LUAD	MIR1231 →	+0.170	+4.108	<.001	.007	3	3
UCEC	PPP2R2D →	+0.249	+3.127	.008	<.001	3	3
UCEC	RIC8A →	+0.350	+2.403	.002	<.001	3	3
UCEC	RNU6-1213P →	+0.189	+3.484	<.001	<.001	3	3
UCEC	RFC5 →	+0.567	+2.042	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,089 associations by consensus.

UBL4A by SERPINI2 expression — UCEC

Explore this box plot interactively →